HCID 86726875, compound → HCID 77844341, compound

HRID 924407Notes

Reaction equation

HRID 924407 reaction equation
[NH2:1][C:2]1[C:3]([C:14]([NH:16][C:17]2[C:18]([N:27]3[CH2:32][CH2:31][CH2:30][C@H:29]([NH2:33])[CH2:28]3)=[C:19]3[CH2:25][CH2:24][C@@H:23]([OH:26])[C:20]3=[N:21][CH:22]=2)=[O:15])=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([CH2:12][CH3:13])[CH:6]=2.NC1C(C(NC2C(N3CCC[C@H](N)C3)=C3CC[C@H](O)C3=NC=2)=O)=NC2C(C=1)=CC=C(CC)C=2>>[NH2:1][C:2]1[C:3]([C:14]([NH:16][C:17]2[C:18]([N:27]3[CH2:32][CH2:31][CH2:30][C@H:29]([NH2:33])[CH2:28]3)=[C:19]3[CH2:25][CH2:24][CH:23]([OH:26])[C:20]3=[N:21][CH:22]=2)=[O:15])=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([CH2:12][CH3:13])[CH:6]=2

Participants

3

Reactant 2

HCID 86726875HCID 86726875, compoundHCID 86726876HCID 86726876, compound

Product 1

HCID 77844341HCID 77844341, compound

Procedure

The diastereoisomers are assigned as 3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-(7R)-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-7-ethylquinoline-2-carboxamide and 3-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-(7S)-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-7-ethylquinoline-2-carboxamide.

Sources & evidence

ORD record
ord-de06c18ff3f840798957715df89efd39
Source dataset
uspto-grants-2016_03
Patent number
US09278950B2

Reaction notes

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