反应详情

To a solution of 3-{[(benzyloxy)carbonyl]amino}-7-vinylquinoline-2-carboxylic acid (673.9 mg, 1.934 mmol) in MeOH (25.0 mL) was added 10 wt % Pd on carbon (100.1 mg, 0.09406 mmol). The mixture was stirred at room temperature hydrogen (1 atm) for 15 h. The reaction mixture was filtered through a pad of diatomaceous earth (eluted with MeOH) and then concentrated under reduced pressure. The resulting crude sub-title compound was used directly in the next step residue without further purification (380.6 mg, 91%). LCMS calc. for C12H13N2O2 (M+H)+: m/z=217.1. found 217.0.

1. filtrationThe reaction mixture was filtered through a pad of diatomaceous earth (eluted with MeOH)
2. concentrationconcentrated under reduced pressure
3. customThe resulting crude sub-title compound was used directly in the next step residue without further purification (380.6 mg, 91%)