反应详情

34.1 g 2,2-Dimethyl-N-(2-morpholin-4-yl-ethyl)-malonamic acid ethyl ester, 8.4 g potassium hydroxide, 200 ml ethanol and 4.5 ml H2O were stirred at 80° C. for 6 hours. Then most of the solvent was removed and the pH was adjusted to pH 3-4 with about 100 ml 2N HCl. The solvent was evaporated and toluol was added and then removed. To the final residue methanol was added and the suspension was filtered to remove salts. The solvent was removed and the residue was dissolved in H2O and lyophilized. The product was characterized by 1H-NMR.

1. customThen most of the solvent was removed
2. customThe solvent was evaporated
3. additiontoluol was added
4. customremoved
5. additionTo the final residue methanol was added
6. filtrationthe suspension was filtered
7. customto remove salts
8. customThe solvent was removed
9. dissolutionthe residue was dissolved in H2O