HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 924658Generated: October 25, 2026
Dimethylformamide → Ethyl 4-bromo-3,5-diethoxybenzoate
https://huagongshe.com/reaction/924658
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromo-3,5-dihydroxybenzoic acid | HCID 86023 | — |
| Product | Ethyl 4-bromo-3,5-diethoxybenzoate | HCID 10663268 | 93% |
Reaction Steps
A mixture of 4-bromo-3,5-dihydroxybenzoic acid (2.0 g, 8.6 mmol), EtI (6.7 g, 43.0 mmol) and K2CO3 (5.9 g, 43.0 mmol) in DMF (20 mL) was stirred at 50° C. overnight. Followed standard aqueous/EtOAc workup (2.5 g, yield 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09283213B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-e52b72e3904d44a89b53f069d451e8e2 |
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| Source note | uspto-grants-2016_03 |
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