Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | HCID 86669353 | HCID 86669353 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 86669338 | HCID 86669338 | 88.7% |
Reaction Steps
To the solution of 4-hydroxy-3-(2-hydroxyethoxyl)benzaldehyde in acetic acid (5 mL) was added 65% nitric acid (34.6 mg, 0.55 mmol) at 0° C., and the mixture was stirred at 0° C. 4 hours. The reaction mixture was poured into ice water followed by a standard aqueous/EtOH workup. Isolated 110 mg, yield 88.7% of Intermediate 10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09283213B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-1b1bda67e2a2401caccc9da71fb8dc22 |
|---|
| Source note | uspto-grants-2016_03 |
|---|
