Hydrochloric Acid → 2-Fluoro-4-formyl-6-hydroxybenzoic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 2-fluoro-4-formyl-6-hydroxybenzoate (Intermediate 7) (300 mg, 1.50 mmol) and aqueous NaOH (2 M, 10 mL) in MeOH (10 mL) was stirred at 20° C. for 5 hours. The mixture was acidified with aqueous HCl until pH=2 followed by a standard aqueous/EtOH workup. The residue was used for next step without further purification.

Provenance & Evidence