Methylamine → 1-(4-Chloro-phenyl)-2-methylamino-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol

Participants

Role	Name	HCID	Charge
Reactant	Methylamine	HCID 6329	—
Reactant	2-(4-Chloro-phenyl)-2-[4-(1H-pyrazol-4-yl)-phenyl]-morpholine	HCID 11461921	—
Reactant	1-(4-Chloro-phenyl)-2-(2-hydroxy-ethylamino)-1-(4-iodo-phenyl)-ethanol	HCID 59331967	—
Product	1-(4-Chloro-phenyl)-2-methylamino-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol	HCID 11381846	—

Reaction Steps

By following the procedure described in Example 79A, 79B and 79D but substituting ethanolamine for methylamine, the title compound was obtained. LCMS (PS-A3) Rt 5.28 min [M+H]+ 328, [M−H2O+H]+ 310. 1H NMR (Me-d3-OD) δ 2.38 (3H, s), 3.34 (2H, s), 7.28-7.31 (2H, m), 7.41-7.46 (4H, m), 7.51-7.54 (2H, m), 7.92 (2H, s).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09283226B2
Source dataset	uspto-grants-2016_03
ORD ID	ord-0d4b7f8619dc46b58c8c9d6df5adce33
Source note	uspto-grants-2016_03