4-Bromo-1-chloro-2-fluorobenzene → 1-(4-Chloro-3-fluorophenyl)-2-phenylethanone

HRID 924939Notes

Reaction equation

HRID 924939 reaction equation
ClC1C=C([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)C=C(Cl)C=1.Br[C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[C:21]([F:26])[CH:20]=1>>[Cl:25][C:22]1[CH:23]=[CH:24][C:19]([C:9](=[O:17])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:20][C:21]=1[F:26]

Participants

3

Reactant 2

HCID 27246904-Bromo-1-chloro-2-fluorobenzeneHCID 27581461-(3,5-Dichlorophenyl)-2-phenylethanone

Product 1

HCID 27575671-(4-Chloro-3-fluorophenyl)-2-phenylethanoneYield 18.2%

Procedure

Prepared following the procedure described in Intermediate 13, starting from 4-bromo-1-chloro-2-fluorobenzene, where the crude product was purified by column chromatography (PE:EtOAc=100:1) to afford Intermediate 16 (200 mg, yield 18.2%).

Workup

  1. customPrepared
  2. customwas purified by column chromatography (PE:EtOAc=100:1)

Sources & evidence

ORD record
ord-3f0a48f54d774f5e85868eed3165721f
Source dataset
uspto-grants-2016_03
Patent number
US09283229B2

Reaction notes

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