HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-3,5-difluorobenzene → 3',5'-Difluoro-2-phenylacetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-3,5-difluorobenzene | HCID 136313 | — |
| Reactant | 1-(3,5-Dichlorophenyl)-2-phenylethanone | HCID 2758146 | — |
| Product | 3',5'-Difluoro-2-phenylacetophenone | HCID 2758319 | 10.3% |
Reaction Steps
Prepared following the procedure described in Intermediate 13, starting from 1-bromo-3,5-difluorobenzene, where the crude product was purified by column chromatography (PE:EtOAc=100:1) to afford Intermediate 18 (100 mg, yield 10.3%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09283229B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-e8ca61853aff4f78805852f251cb860b |
| Source note | uspto-grants-2016_03 |