HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-2-fluorobenzene → 1-(2-Fluorophenyl)-2-phenylethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-2-fluorobenzene | HCID 61259 | — |
| Reactant | 1-(3,5-Dichlorophenyl)-2-phenylethanone | HCID 2758146 | — |
| Product | 1-(2-Fluorophenyl)-2-phenylethan-1-one | HCID 12693379 | 33.5% |
Reaction Steps
Prepared from 1-bromo-2-fluorobenzene following the procedure described in Intermediate 13, where the crude product was purified by column chromatography (PE:EtOAc=100:1) to afford Intermediate 24 (300 mg, yield 33.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09283229B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-c777a5d9beaf4e7699a3c9991c2305d3 |
| Source note | uspto-grants-2016_03 |