HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methoxy-N-methylnicotinamide → 2-Phenyl-1-pyridin-3-yl-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methoxy-N-methylnicotinamide | HCID 10558996 | — |
| Reactant | 3,4-Dimethoxy-2-phenylacetophenone | HCID 12336683 | — |
| Reactant | HCID 178418336 | HCID 178418336 | — |
| Product | 2-Phenyl-1-pyridin-3-yl-ethanone | HCID 4328900 | 19% |
Reaction Steps
Followed the procedure described in Step 2 of Intermediate 7 with N-methoxy-N-methylnicotinamide and benzylmagnesium chloride, where the mixture was stirred for 3 hours. Purification was achieved by column chromatography (PE:EtOAc=5:1) to give Intermediate 31 (110 mg, yield 19%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09283229B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-32cb007b48644d878438f20a3895bf90 |
| Source note | uspto-grants-2016_03 |