HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 924957Generated: October 26, 2026
Ethyl Acetate → 3-Ethoxy-5-formyl-2-hydroxybenzonitrile
https://huagongshe.com/reaction/924957
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3-Bromo-5-ethoxy-4-(methoxymethoxy)benzaldehyde | HCID 65364447 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Ethoxy-5-formyl-2-hydroxybenzonitrile | HCID 86669332 | 50% |
Reaction Steps
A mixture of 3-bromo-5-ethoxy-4-(methoxymethoxy)benzaldehyde (600 mg, 2.1 mmol) and CuCN (280 mg, 3.1 mmol) in DMF (10 mL) was heated at 180° C. for 4 hours. TLC (PE:EtOAc=1:1) indicated that the most of the starting material was consumed. The solvent was removed in vacuo, and the residue was purified by column chromatograph to afford 3-ethoxy-5-formyl-2-hydroxybenzonitrile (200 mg, yield: 50.0%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09283229B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-0f6487901a0b4377add9e29c99e22624 |
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| Source note | uspto-grants-2016_03 |
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