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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 924974Generated: October 30, 2026

1-Bromo-4-fluorobenzene → 1-(4-Fluorophenyl)-2-(thiophen-3-yl)ethanone

https://huagongshe.com/reaction/924974

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-4-fluorobenzeneHCID 9993—
Reactant1-(1,1'-Biphenyl)-4-yl-2-phenylethan-1-oneHCID 74817—
Reactant1-Phenyl-2-(thiophen-3-yl)ethanoneHCID 12233113—
Product1-(4-Fluorophenyl)-2-(thiophen-3-yl)ethanoneHCID 6105405445%

Reaction Steps

Followed the procedure described in synthesis of Intermediate 14 using N-methoxy-N-methyl-2-(thiophen-3-yl)acetamide (prepared in Step 1 of Intermediate 2) and 1-bromo-4-fluorobenzene to give Intermediate 54, (260 mg, 45%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09283229B2
Source datasetuspto-grants-2016_03
ORD IDord-0172d6f435df4a3686d48d2bf399db36
Source noteuspto-grants-2016_03