Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | HCID 67060957 | HCID 67060957 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67060955 | HCID 67060955 | 87.6% |
Reaction Steps
A mixture of ethyl 4-hydroxy-3-nitro-5-propylbenzoate (1.5 g, 5.9 mmol), TBSCl (1.3 g, 8.9 mmol) and imidazole (800 mg, 11.8 mmol) in DMF (20 mL) was stirred at 30° C. overnight. A standard aqueous/EtOAc workup was followed by a purification by column chromatography (PE:EtOAc=15:1) to give product as a yellow oil (1.9 g, yield 86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09283229B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-1f3d015afe4841edb67d9cd8f5a78c7d |
|---|
| Source note | uspto-grants-2016_03 |
|---|
