反应详情

Procedure as described for NP Amidine I using the following amounts: 1.33 g of N1-(2-isopropyl-6-methylphenyl)-4-methylbenzamidine (Amidine V, 5.0 mmol), 2.50 mL of 2.0 M butyllithium (5.0 mmol), 0.93 mL chlorodiphenylphosphine (5.0 mmol). After filtration to remove lithium chloride and removal of solvent, the residue was treated with 20 mL of pentane. Prolonged stirring deposited a beige solid which was collected and dried (1.62 g, 72%).

1. filtrationAfter filtration
2. customto remove
3. customlithium chloride and removal of solvent
4. additionthe residue was treated with 20 mL of pentane
5. customwas collected
6. customdried (1.62 g, 72%)