Chlorodiisopropylphosphine → HCID 178460692, compound

HRID 925053Notes

Reaction equation

HRID 925053 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][NH:9][C:10](=[NH:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:3][CH2:2]1.C([Li])CCC.Cl[P:24]([CH:28]([CH3:30])[CH3:29])[CH:25]([CH3:27])[CH3:26]>>[CH:25]([P:24]([CH:28]([CH3:30])[CH3:29])[N:17]=[C:10]([NH:9][CH2:8][CH2:7][N:4]1[CH2:3][CH2:2][O:1][CH2:6][CH2:5]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([CH3:27])[CH3:26]

Participants

4

Reactant 3

HCID 538967ChlorodiisopropylphosphineHCID 178418339ButyllithiumHCID 178512208HCID 178512208, compound

Product 1

HCID 178460692HCID 178460692, compound

Procedure

Procedure as described for NP Amidine XVII using the following amounts: 0.956 g of N1-(2-morpholinoethyl)benzamidine (Amidine XV, 5.0 mmol), 2.50 mL of 2.0 M butyllithium (5.0 mmol), 0.80 mL chlorodiisopropylphosphine (5.0 mmol). After filtration to remove lithium chloride and removal of solvent, a yellow oil was isolated (1.71 g, 98%).

Workup

  1. filtrationAfter filtration
  2. customto remove
  3. customlithium chloride and removal of solvent
  4. customa yellow oil was isolated (1.71 g, 98%)

Sources & evidence

ORD record
ord-50e1eb3e883543ccb855dd19dddd2aa2
Source dataset
uspto-grants-2016_03
Patent number
US09283555B2

Reaction notes

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