Triethylamine → Methyl 3-((3-oxo-4,5,6,7-tetrahydroisobenzofuran-1(3h)-ylidene)methyl)benzoate

Participants

Reaction Steps

A solution of EXAMPLE 1B (25.8 g, 61.5 mmol), methyl-3-formylbenzoate (10.01 g, 61.0 mmol), and triethylamine (8.7 mL, 62.4 mmol) in dichloromethane (125 mL) was stirred at room temperature for 16 hours, and concentrated. The residue was stirred with a mixture of ethyl acetate and water. The precipitated solid was filtered, washed with water, and dried to provide the title compound. MS (DCI/NH3) m/z 285 (M+H)+.

Provenance & Evidence