3,4,5,6-Tetrahydrophthalic anhydride → 3-(3-bromo-4-fluorophenyl)-3-methoxy-4,5,6,7-tetrahydroisobenzofuran-1(3H)-one

Temperature

0 °C

To a solution of 2-bromo-1-fluoro-4-iodobenzene (13.23 g, 44 mmol) in anhydrous tetrahydrofuran (30 mL) was added isopropylmagnesium chloride (2.0 M solution in tetrahydrofuran, 24.18 mL, 48.4 mmol) at −20° C. After the addition, the reaction mixture was stirred at 0° C. for 3 hours, and was added to a solution of 3,4,5,6-tetrahydrophthalic anhydride (6.08 g, 40 mmol) in anhydrous tetrahydrofuran (60 mL) at −78° C. The mixture was stirred for 2 hours, and a saturated aqueous ammonium chloride solution was added to the reaction mixture, which then was stirred at room temperature for 30 minutes. Anhydrous magnesium sulfate was added to the reaction mixture, and the mixture was filtered. The filtrate was concentrated. Thionyl chloride (10.4 mL, 142 mol) was added dropwise to methanol (40 mL) at −10° C., and the solution was stirred at 0° C. for 30 minutes. To the thionyl chloride solution was then added the residue from the filtrate in anhydrous methanol (15 mL). The reaction mixture was stirred at room temperature overnight, and was concentrated. The residue was dissolved in methylene chloride (40 mL), and was treated with triethylamine (5.58 mL) at 0° C. for 1 hour. Water was added, and the mixture was washed with sodium bicarbonate, brine and water. The organic phase was dried over magnesium sulfate, filtered and concentrated. The residue was separated by flash chromatography (10-35% gradient ethyl acetate in hexane) to provide the title compound. MS (DCI/NH3) m/z 341, 343 (M+H)+.

1. additionAfter the addition
2. stirringThe mixture was stirred for 2 hours
3. stirringthen was stirred at room temperature for 30 minutes
4. filtrationthe mixture was filtered
5. concentrationThe filtrate was concentrated
6. stirringthe solution was stirred at 0° C. for 30 minutes
7. stirringThe reaction mixture was stirred at room temperature overnight
8. concentrationwas concentrated
9. dissolutionThe residue was dissolved in methylene chloride (40 mL)
10. additionwas treated with triethylamine (5.58 mL) at 0° C. for 1 hour
11. additionWater was added
12. washthe mixture was washed with sodium bicarbonate, brine and water
13. dry with materialThe organic phase was dried over magnesium sulfate
14. filtrationfiltered
15. concentrationconcentrated
16. customThe residue was separated by flash chromatography (10-35% gradient ethyl acetate in hexane)

ORD record

ord-29276a4827d34bef9f1fa84545e7de19

Source dataset

uspto-grants-2016_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09283222B2