反应详情

Into a reaction vessel were charged 31.2 parts by weight of (3R)-1,1,3-trimethyl-4-aminoindane (optical purity of 67.0% ee) and 0.83 part by weight of 4.5% palladium-0.5% platinum-carbon (ASCA-2, manufactured by N. E. Chemcat Corporation), thereby obtaining a mixture. The reaction vessel was sealed and the gas in the reaction vessel was replaced with nitrogen. While the mixture was stirred, into the reaction vessel was charged hydrogen until the internal pressure of hydrogen in the reaction vessel reached 0.5 MPa, and the mixture was stirred at an internal temperature of 60° C. After 1 hour, the gas in the reaction vessel was replaced with nitrogen, and the mixture was stirred at an internal temperature of 180° C. and an internal pressure of 0.3 MPa for 12.5 hours, thereby obtaining a reaction mixture. The obtained reaction mixture was cooled and filtered. The obtained solid was washed with 45 parts by weight of toluene. The washing liquid recovered after washing and the filtrate obtained by filtration were combined to obtain a solution of 77.5 parts by weight of 1,1,3-trimethyl-4-aminoindane in toluene. The combined 1,1,3-trimethyl-4-aminoindane had an optical purity of 0.29% ee and a recovery rate of 97.7%.

1. customobtaining a mixture
2. customThe reaction vessel was sealed
3. stirringthe mixture was stirred at an internal temperature of 60° C
4. stirringthe mixture was stirred at an internal temperature of 180° C.
5. waitan internal pressure of 0.3 MPa for 12.5 hours
6. customobtaining a reaction mixture
7. customThe obtained reaction mixture
8. temperaturewas cooled
9. filtrationfiltered
10. washThe obtained solid was washed with 45 parts by weight of toluene
11. customThe washing liquid recovered
12. washafter washing
13. customthe filtrate obtained by filtration