HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 925122Generated: October 30, 2026
1-(4-(Benzyloxy)-5-methoxy-2-nitrophenyl)-cyclobutanecarbonitrile → 1-(4-Hydroxy-5-methoxy-2-nitrophenyl)cyclobutanecarbonitrile
https://huagongshe.com/reaction/925122
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-(4-(Benzyloxy)-5-methoxy-2-nitrophenyl)-cyclobutanecarbonitrile | HCID 101043616 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(4-Hydroxy-5-methoxy-2-nitrophenyl)cyclobutanecarbonitrile | HCID 92135129 | 99% |
Reaction Steps
A solution of 1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)cyclobutanecarbonitrile (2.78 g, 8.22 mmol), from Step 2, in EtOH (30 mL) was treated with 10% Pd/C (0.87 g, 0.822 mmol), fitted with hydrogen filled balloon and heated to 70° C. for 3 hours under hydrogen atmosphere. The catalyst was filtered off and washed with EtOH. Solvent was concentrated to provide 1-(4-(hydroxyl)-5-methoxy-2-nitrophenyl)cyclobutanecarbonitrile (2 g, 99%). MS (ESI) m/z 249 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09284272B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-33c61dc6ceca4f408ae5c37228645f07 |
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| Source note | uspto-grants-2016_03 |
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