2,5-Hexanedione → HCID 57329198, compound

HRID 925171Notes

Reaction equation

HRID 925171 reaction equation
[NH2:1][C:2]1[C:3]([O:20][CH3:21])=[CH:4][C:5]([CH:17]([CH3:19])[CH3:18])=[C:6]([CH:16]=1)[O:7][C:8]1[C:9]([NH2:15])=[N:10][C:11]([NH2:14])=[N:12][CH:13]=1.CC(=O)CCC(=[O:28])C.C[C:31]1[N:32]([C:37]2[C:38](OC)=[CH:39][C:40](C(C)C)=[C:41]([CH:51]=2)OC2C(N)=NC(N)=NC=2)C(C)=CC=1>>[NH2:14][C:11]1[N:10]=[C:9]([NH2:15])[C:8]([O:7][C:6]2[C:5]([CH:17]([CH3:19])[CH3:18])=[CH:4][C:3]([O:20][CH3:21])=[C:2]([NH:1][C:31]([NH:32][C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:51]=3)=[O:28])[CH:16]=2)=[CH:13][N:12]=1

Participants

4

Reactant 3

HCID 80352,5-HexanedioneHCID 57329274HCID 57329274, compoundHCID 595985735-(5-Amino-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine

Product 1

HCID 57329198HCID 57329198, compound

Procedure

Similarly prepared from 5-(5-amino-2-Isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine (0.313 g, 1.1 mmol) and 2,5-hexanedione (0.14 ml, 1.2 mmol) was 5-[5-(2,5-Dimethyl-pyrrol-1-yl)-2-isopropyl-4-methoxy-phenoxy]-pyrimidine-2,4-diamine, (0.259 g, 64%). (M+H)=368.

Sources & evidence

ORD record
ord-5e16e4109b9b473782dd3286ccde539a
Source dataset
uspto-grants-2016_03
Patent number
US09284279B2

Reaction notes

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