HCID 86725305, compound → HCID 86725307, compound

HRID 925191Notes

Reaction equation

HRID 925191 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:21][CH2:20][C:10]2=[CH:11][C:12](Br)=[C:13]3[C:17]([C:16]([CH3:18])=[CH:15][CH2:14]3)=[C:9]2[CH2:8][CH2:7]1)=[O:5])[CH3:2].[H][H]>CCO.[Pd]>[CH2:1]([O:3][C:4]([N:6]1[CH2:7][CH2:8][C:9]2[C:17]3[CH:16]([CH3:18])[CH2:15][CH2:14][C:13]=3[CH:12]=[CH:11][C:10]=2[CH2:20][CH2:21]1)=[O:5])[CH3:2]

Participants

5

Reactant 2

HCID 86725305HCID 86725305, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86725307HCID 86725307, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Into a 500 ml Parr hydrogenation bottle, the product from step (b) (80 mg, 0.23 mmol) dissolved in EtOH (50 ml) was placed. To the argon purged bottle, 10% Pd—C (wet, 100 mg) was added. The bottle was shaken over hydrogen (50 psi) for 3 h. The reaction mixture was filtered through celite and solvent evaporated in vacuo to give the sub-titled compound as colorless oil. MS: ESI (positive): 274 (M+1).

Workup

  1. filtrationThe reaction mixture was filtered through celite and solvent
  2. customevaporated in vacuo

Sources & evidence

ORD record
ord-7730aa10fe894fee9ad54440c63688e0
Source dataset
uspto-grants-2016_03
Patent number
US09284277B2

Reaction notes

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