HCID 86725303, compound → HCID 86725308, compound

Participants

Reaction Steps

Into a stirred 100 ml flask containing Intermediate 3 (200 mg, 0.732 mmol) dissolved in diethyl ether (20 ml), cyclopropylmagnesium bromide (0.5M in THF, 7.32 ml, 3.66 mmol) was added at reflux. The reaction mixture was stirred at reflux for 1 hour. The reaction mixture was allowed to cool to room temperature and was quenched by addition of 10% aq. NH4Cl (50 ml). The aqueous mixture was extracted with EtOAc (3×). The combined EtOAc extracts were washed with brine, dried over Na2SO4, and solvent evaporated in vacuo to give the sub-titled compound which was used without further purification. MS: ESI (positive): 298, (M-OH).

Provenance & Evidence