3-Bromopyridine → HCID 86725312, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 3-bromopyridine (0.11 ml, 1.13 mmol) in THF (5 ml) under Ar at −78° C., n-BuLi (2.5 M in hexane, 0.45 ml, 1.13 mmol) was added. The mixture was stirred at −78° C. for 20 minutes, followed by dropwise addition of Intermediate 1 (0.15 g, 0.38 mmol) in THF (5 ml). The mixture was stirred for 2 h at −78° C., allowed to warm to room temperature, and quenched by slow addition of aqueous saturated NH4Cl (50 ml). The mixture was extracted with EtOAc (3×). The combined EtOAc extracts were washed with brine, dried (Na2SO4), and solvent evaporated in vacuo to give the sub-title compound as tan oil that was used without further purification. MS: ESI (positive): 479 (M+1).

Provenance & Evidence