HCID 86725313, compound → HCID 86725315, compound

Participants

Reaction Steps

Into a 500 ml Parr hydrogenation bottle, the product from step (b) (0.38 mmol) dissolved in EtOH (50 ml) was added. To the argon purged bottle, 100 mg of 20% Pd(OH)2 was placed. The bottle was shaken over hydrogen (50 psi) for 6 h. The reaction mixture was filtered through celite and solvent evaporated in vacuo. The residue was dissolved in DCM and washed with saturated aqueous Na2CO3. The DCM layer was dried over Na2SO4 and solvent was evaporated in vacuo to give the crude product that was purified by silica-gel chromatography (gradient elution: 0 to 80% EtOAc in hexane) to give the sub-title compound as a yellow oil (70 mg). MS: ESI (positive): 337 (M+1).

Provenance & Evidence