HCID 86725322, compound → HCID 86725324, compound

Participants

Reaction Steps

Into a glass vial containing the product from step (b) (130 mg, 0.385 mmol) in diethyl ether (5 ml), 2-methoxyphenyl magnesium bromide (3.85 ml, 1.92 mmol) was added. The reaction mixture was stirred at reflux for 30 minutes. The reaction was cooled to room temperature, quenched with of 10% aqueous NH4Cl (50 ml), and extracted with EtOAc (3×). The combined EtOAc extracts were washed with brine, dried over Na2SO4, and the solvent evaporated in vacuo to give the crude product. Purification by silica-gel chromatography (gradient elution: 0 to 40% EtOAc in hexanes) gave the sub-title compound as a yellow oil (145 mg). MS: ESI (positive): 446 (M+1).

Provenance & Evidence