Pyridine → HCID 86725325, compound

Participants

Reaction Conditions

Reaction Steps

Into a 500 ml flask containing the product from step (a) (5.9 g, 15.20 mmol) in DCE (50 ml), thionyl bromide (5.89 ml, 76.03 mmol) was added, followed by pyridine (123 μL, 1.52 mmol). The stirred reaction mixture was heated to 70° C. for 30 minutes. The reaction mixture was then allowed to cool to room temperature and was carefully poured over ice-cold saturated aqueous Na2CO3 and extracted with DCM (3×). The combined DCM extracts were washed with brine, dried over Na2SO4, and solvent evaporated in vacuo to give the sub-title compound as a pale red semi-solid that was used without further purification. MS: ESI (positive): 451, 453 (M+1).

Provenance & Evidence