HCID 86725329, compound → HCID 86725328, compound

Participants

Reaction Steps

Into a 100 ml flask, the product from step (a) dissolved in EtOH (20 ml) was added. The flask was purged with Ar and 10% Pd—C (15 mg) was added. The reaction was stirred over hydrogen (atmospheric pressure) for 16 hours. The reaction mixture was filtered through celite and the solvent evaporated in vacuo. The crude residue was purified by silica-gel chromatography (gradient elution: 0 to 20% EtOAc in hexanes) to give the sub-title product as a colorless oil (42 mg). 1H NMR (300 MHz, CDCl3) δ 7.02-6.96 (m, 2H); 4.17 (q, J=7.2 Hz, 2H); 3.65-3.56 (m, 4H); 3.49-3.21 (m, 3H) 2.89-2.83 (m, 4H); 1.76-1.56 (m, 2H); 1.28 (t, J=6.9 Hz, 3H); 0.94 (t, J=7.5 Hz, 3H); MS: ESI (positive): 324 (M+1).

Provenance & Evidence