N-bromobutanimide → HCID 86725335, compound

Participants

Reaction Conditions

Reaction Steps

Into a 100 ml flask, the product of step (d) (1.65 g, 6.37 mmol) dissolved in acetonitrile (25 ml) was added. To this stirred solution, NBS (1.07 g, 6.05 mmol) was added. The reaction mixture was heated to 80° C. for 15 minutes and then partitioned between water and EtOAc. The aqueous layer was extracted with EtOAc (3×). The combined EtOAc extracts were washed with brine, dried over Na2SO4, and solvent evaporated in vacuo to give the crude product. Purification by silica-gel chromatography (gradient elution: 0 to 40% EtOAc in hexanes) gave the sub-title compound as a yellow solid (1.4 g). MS: ESI (positive): 338, 340 (M+H).

Provenance & Evidence