Potassium Carbonate → HCID 76684541, compound

Participants

Reaction Steps

The product of step (i) (45 mg, 0.143 mmol) was dissolved in an appropriately sized flask in MeOH (3 ml). To this mixture water (1 ml) and K2CO3 (500 mg, 3.62 mmol) were added. The reaction mixture was stirred at room temperature until the product formation was complete by LCMS. The reaction mixture was diluted with water (>10× total volume) and extracted with DCM (3×). The combined DCM extracts were washed with brine, dried (Na2SO4), and solvent evaporated in vacuo to provide the title compound (15.8 mg). 1H NMR (300 MHz, CDCl3) δ 6.86 (d, J=7.8 Hz, 1H); 6.52 (d, J=8.1 Hz, 1H); 4.49-4.44 (m, 1H); 4.39-4.35 (m, 1H); 3.31-3.21 (m, 1H); 2.99-2.85 (m, 8H); 2.07 (bs, 1H); 1.58-1.52 (m, 2H); 0.92 (t, J=7.5 Hz, 3H). MS: ESI (positive): 218 (M+H).

Provenance & Evidence