Methyl iodide → HCID 86725357, compound

Participants

Reaction Steps

To a stirred solution of the product from step (a) (45 mg, 0.16 mmol) in DMF (2 ml) at RT over an argon atmosphere was added NaH (16 mg, 0.41 mmol). The reaction mixture was stirred until gas evolution had ceased and then iodomethane (0.025 ml, 0.41 mmol) was added. The reaction mixture was stirred at RT for 24 hours. The reaction mixture was diluted with water and extracted with ethyl acetate (3×). The combined ethyl acetate extracts were washed with brine, dried (Na2SO4), and solvent evaporated in vacuo to give the sub-titled compound as a colorless oil (52 mg). MS: ESI (positive): 290 (M+H).

Provenance & Evidence