Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | Citalopram Hydrobromide | HCID 77995 | — |
| Product | HCID 178464549 | HCID 178464549 | 19% |
Reaction Steps
Using 250 mg of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile hydrobromide (citalopram HBr, 1.0 equiv) and ethylamine (1.3 equiv) gave, after heating at 80° C. for 15 h, the title product (65 mg, 19% yield) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09284291B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-a15aba9e6f8b4a69baffa2d4e10f920b |
|---|
| Source note | uspto-grants-2016_03 |
|---|
