反应详情

温度

75 °C

Sodium hydroxide (0.29 g, 7.27 mmol) is added to a solution of 4-(2-methoxycarbonyl-ethylsulfanyl)-thiazole-5-carboxylic acid methyl ester (2.0 g, 7.27 mmol) in MeOH (30 ml). The mixture is refluxed at 70-80° C. for 1 h and then concentrated in vacuo. The residue is dissolved in EtOAc/water (1:1) (80 ml) and the pH is adjusted to 2 with 2M hydrochloric acid. The organic layer is dried over sodium sulfate and concentrated yielding 4-mercapto-thiazole-5-carboxylic acid methyl ester (0.82 g, 4.67 mmol, 46%).

1. concentrationconcentrated in vacuo
2. dissolutionThe residue is dissolved in EtOAc/water (1:1) (80 ml)
3. dry with materialThe organic layer is dried over sodium sulfate
4. concentrationconcentrated