HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 2-(6-chloro-5-methyl-1H-indol-3-yl)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3-(2-azidoethyl)-6-chloro-5-methyl-2-(triethylsilyl)-1H-indole | HCID 86663837 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Product | 2-(6-chloro-5-methyl-1H-indol-3-yl)ethanamine | HCID 66832155 | — |
Reaction Steps
2-(6-chloro-5-methyl-1H-indol-3-yl)ethanamine was prepared according to method D Step V with 3-(2-azidoethyl)-6-chloro-5-methyl-2-(triethylsilyl)-1H-indole (0.654 g; 1.87 mmol) and triphenylphosphine (0.737 g; 2.81 mmol) in methanol (10 mL) and tetrabutylamonium fluoride (5.62 mL 1M) in THF (stirred for 36 hours).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284271B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-1e0b12811f2843d788b87ddd7459b3cf |
| Source note | uspto-grants-2016_03 |