Iodine → 4-Amino-3-iodobenzonitrile

Participants

Reaction Steps

4-amino-3-iodobenzonitrile was prepared according to method D Step I with Iodine (0.645 g; 2.54 mmol), silver sulphate (0.791 g; 2.54 mmol) and 4-aminobenzonitrile (0.300 g; 2.54 mmol) in ethanol (10 mL). The crude residue was purified by flash chromatography on silica gel (eluent 2 to 40% ethyl acetate in heptane) to yield 0.222 g (36%) of 4-amino-3-iodobenzonitrile as a white solid.

Provenance & Evidence