反应详情

3,4,5-trifluoro-2-iodoaniline was prepared according to method D Step I with iodine (0.621 g; 2.45 mmol), silver sulphate (0.763 g; 2.45 mmol) and 3,4,5-trifluoroaniline (0.360 g; 2.45 mmol) in ethanol (5 mL). The crude residue was purified by flash chromatography on silica gel (eluent 2 to 40% ethyl acetate in heptane) to yield 0.279 g (42%) of 3,4,5-trifluoro-2-iodoaniline as a white solid.

1. custom3,4,5-trifluoro-2-iodoaniline was prepared
2. customThe crude residue was purified by flash chromatography on silica gel (eluent 2 to 40% ethyl acetate in heptane)