HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 1835789, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Phenylbenzoyl chloride | HCID 84151 | — |
| Reactant | 5-Chloro-1H-indole-3-ethylamine monohydrochloride | HCID 2827494 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 1835789 | HCID 1835789 | 79% |
Reaction Steps
N-(2-(5-Chloro-1H-indol-3-yl)ethyl)biphenyl-4-carboxamide was obtained following Method C starting from 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.100 g, 0.424 mmol), biphenyl-4-carbonyl chloride (0.098 g; 0.445 mmol), and triethylamine (0.131 mL; 0.934 mmol) in dichloromethane (5 mL). Flash chromatography on silica gel (eluent 10% ethyl acetate in dichloromethane) furnished 0.125 g (79%) of N-(2-(5-Chloro-1H-indol-3-yl)ethyl)biphenyl-4-carboxamide as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284271B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-97508a68eda64f59bb285b79df11b914 |
| Source note | uspto-grants-2016_03 |