HCID 89740577, compound → HCID 71695775, compound

Participants

Reaction Steps

To a solution of N-((2H-tetrazol-5-yl)methyl)-1-(benzyloxy)-1H-indazol-5-amine (43 mg, 0.14 mmol) in dry MeOH (10 mL) was added 10% Pd on charcoal (5 mg). The reaction was stirred under hydrogen atmosphere overnight, and then the solution was filtered over filter paper. Solvent was removed using a rotatory evaporator to provide the desired product, 76, (32 mg, 0.14 mmol) as a pale green solid in quantitative yield. 1H NMR (500 MHz, DMSO) δ 7.95 (s, 1H), 7.72 (s, 1H), 7.60 (d, J=8.5 Hz, 1H), 7.02 (dd, J=1.5, 8.5 Hz, H), 5.35 (s, 2H). 13C NMR (125 MHz, DMSO) δ 155.90, 140.24, 134.21, 129.74, 127.39, 123.31, 120.85, 110.81, 60.94. MS (ESI, CH3OH): [C9H9N7O] m/z 232.1 ([M+H]+).

Provenance & Evidence