Phenol → HCID 70873494, compound

Participants

Reaction Steps

50 mg (0.142 mmol) of ethyl 1-tert-butyl-5-[2-(methylsulfonyl)pyrimidin-4-yl]-1H-pyrazole-3-carboxylate were dissolved in 1.5 mL of dry DMF, 14.7 mg (0.156 mmol) of phenol and 59 mg (0.426 mmol) of potassium carbonate were added. The final suspension was stirred at 70° C. for 3 h then partitioned between H2O and AcOEt. The organic layer was washed with brine dried over Na2SO4, filtered and concentrated under reduced pressure to provide the title compound (77%).

Provenance & Evidence