(Diethylamino)sulfur trifluoride → HCID 75202655, compound

Participants

Reaction Steps

To a solution of Example 1 (20 mg, 0.051 mmol) in dry CH2Cl2 (2 mL) was added DAST (16 mg, 0.102 mmol) at −78° C. The solution was allowed to warm to room temperature over 1 h at which time LCMS indicated the reaction was complete. The reaction mixture was concentrated and the crude residue was purified by reverse-phase chromatography (5-30% MeOH/H2O) to give Example 2 as a white solid. 1H NMR (400 MHz, CD3OD) δ 7.96-7.86 (m, 3H), 7.74-7.60 (m, 2H), 4.69-4.52 (m, 1H), 4.05 (s, 3H), 3.51-3.34 (m, 4H), 2.91 (s, 3H), 2.55 (s, 3H), 2.41 (s, 3H). MS: m/z=392.2 (M+H).

Provenance & Evidence