HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 89893928, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | HCID 89894133 | HCID 89894133 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 89893928 | HCID 89893928 | 85% |
Reaction Steps
To a solution of (S)-tert-butyl 5-(methylthiomethyl)-2-oxooxazolidin-3-ylcarbamate (374 mg, 1.426 mmol) in THF (2 mL), 4M HCl in dioxane (1.25 mL, 4.99 mmol) was added. The reaction was stirred at r.t. for 4 days and a white solid precipitated. The obtained product was filtered and triturated with hot diisopropyl ether affording the title compound (240 mg, 1.208 mmol). Yield=85%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284306B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-c3066feedcef4c0ea4c492c779d93dc6 |
| Source note | uspto-grants-2016_03 |