HCID 86650269, compound → 2-Amino-2-(5-bromo-2-fluoro-phenyl)-propane-1,3-diol

HRID 925452Notes

Reaction equation

HRID 925452 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:16])=[C:6]([C:8]([N+:13]([O-])=O)([CH2:11][OH:12])[CH2:9][OH:10])[CH:7]=1>CC(O)=O.[Zn]>[NH2:13][C:8]([C:6]1[CH:7]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=1[F:16])([CH2:9][OH:10])[CH2:11][OH:12]

Participants

4

Reactant 1

HCID 86650269HCID 86650269, compound

Product 1

HCID 666658452-Amino-2-(5-bromo-2-fluoro-phenyl)-propane-1,3-diol

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 176Acetic AcidSolvent2×

Procedure

A solution of 2-(5-bromo-2-fluoro-phenyl)-2-nitro-propane-1,3-diol (7 g, 23.8 mmol) in 35 ml AcOH was added dropwise to a mixture of zinc (9.34 g, 143 mmol) in 35 ml AcOH while the temperature did not rise above 40° C. The mixture was stirred for 1 h, filtered over celite and washed with MeOH. The filtrate was evaporated, diluted with water and washed with TBME. The aqueous layer was basified with 2 N NaOH and NH3 (25%, aqueous), saturated with NaCl and extracted with EtOAc. The organic layer was washed with brine, dried with Na2SO4 and evaporated to provide the title compound as an off-white solid.

Workup

  1. customdid not rise above 40° C
  2. filtrationfiltered over celite
  3. washwashed with MeOH
  4. customThe filtrate was evaporated
  5. additiondiluted with water
  6. washwashed with TBME
  7. extractionextracted with EtOAc
  8. washThe organic layer was washed with brine
  9. dry with materialdried with Na2SO4
  10. customevaporated

Sources & evidence

ORD record
ord-119337885e5b45808291e1cbec3dc223
Source dataset
uspto-grants-2016_03
Patent number
US09284284B2

Reaction notes

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