Ammonia methanol → HCID 89500498, compound

Participants

Reaction Steps

A solution of 6.14 g (18.05 mmol) 5-(5-bromo-2-fluoro-phenyl)-5-fluoromethyl-morpholine-3-thione in 77 ml 7M NH3/MeOH was stirred at rt for 15 h. The mixture was evaporated and purified chromatographed on silica gel (DCM/1-5% MeOH followed by DCM/MeOH/aqueous NH3 95:4.5:0.5) to give the desired product as yellowish resin.

Provenance & Evidence