HCID 89500351, compound → HCID 71549815, compound

Participants

Reaction Conditions

Reaction Steps

{5-[5-(4-Bromo-2-chloro-benzylamino)-2-fluoro-phenyl]-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl}-carbamic acid tert-butyl ester (82 mg, 0.151 mmol) were suspended in 1.1 ml HCl/Dioxane (4M). A few drops HCl/MeOH (3M) were added and the mixture was stirred at 50° C. for 2 h. The mixture was evaporated, taken up in 10% aq soda, extracted with DCM and dried with Na2SO4. The title compound was purified via chromatography on silica gel [DCM/1-5%(MeOH/DCM 10:90)]. The product was dissolved in Et2O and precipitated as its hydrochloride salt by adding 1N HCl/Et2O.

Provenance & Evidence