HCID 71550224, compound → HCID 71550508, compound

Participants

Reaction Steps

To a solution of (R)-5-difluoromethyl-5-[2-fluoro-5-(3-methoxy-5-nitro-pyridin-2-ylamino)-phenyl]-5,6-dihydro-2H-[1,4]oxazin-3-ylamine (80 mg, 0.179 mmol) in EtOH (10 ml) was added Pd—C (10%, 50 mg) the mixture was set under an atmosphere of hydrogen and stirred for 1 h. The catalyst was filtered off, the mixture diluted with DCM (20 ml) aq. sat. Na2CO3 (5 ml) was added and stirred for 5 min. The layers were separated, the aq. phase extracted with DCM (20 ml), the combined organic layers were washed with aq. sat. Na2CO3 (5 ml), dried with MgSO4 and the solvent removed under reduced pressure. The residue was purified by prep. TLC on silica gel (DCM/MeOH 9:1) to afford the title compound as purple semi-solid.

Provenance & Evidence