HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 3-Amino-5-(trifluoromethyl)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3-Nitro-5-(trifluoromethyl)picolinonitrile | HCID 45382147 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 3-Amino-5-(trifluoromethyl)picolinamide | HCID 86728156 | — |
Reaction Steps
To a solution of 3-nitro-5-trifluoromethyl-pyridine-2-carbonitrile (1194 g, 5500 mmol) in EtOAc (12 l) was added 450 g Pd/C (10%) and hydrogenated (1.1 bar) at ambient temperature for 7 days. The reaction mixture was filtered and concentrated. The crude product was recrystallized from heptane/DCM to give 880 g of the desired product as a yellowish solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284284B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-0f4f76d86ff04cb3be9f0804485c3329 |
| Source note | uspto-grants-2016_03 |