反应详情

温度

120 °C

A mixture of 3-amino-5-trifluoromethyl-pyridine-2-carboxylic acid amide (500 mg, 2.44 mmol) and triethoxymethane (1.8 g, 12.2 mmol) were heated to 120° C. for 16 h. The mixture was cooled to ambient temperature and treated with low boiling PE. The reaction mixture was stirred for 10 minutes, cooled to 0° C. and the beige solid was collected by filtration (350 mg).

1. temperatureThe mixture was cooled to ambient temperature
2. additiontreated with low boiling PE
3. temperaturecooled to 0° C.
4. filtrationthe beige solid was collected by filtration (350 mg)