Trifluoroacetic acid → HCID 59484884, compound

Participants

Reaction Steps

49.3 70 mg (0.127 mmol) of tert-butyl[3-(2-{3-[6-oxo-3-(3,4,5-trifluorophenyl)-6H-pyridazin-1-ylmethyl]phenyl}pyrimidin-5-yl)propyl]carbamate are dissolved in 3 ml of dichloromethane, and 195 μl (2.54 mmol) of trifluoroacetic acid are added. The reaction mixture is stirred at room temperature for 15 h and evaporated. The residue is digested with diethyl ether and dried in vacuo; yield: 74 mg of “A285”; HPLC: Rt=2.63 min (method C); LC-MS: 452 (M+H).

Provenance & Evidence