Diethyl (ethoxymethylene)malonate → HCID 58379534, compound

Participants

Reaction Steps

6-bromopyridin-3-amine (74 g, 0.43 mol) and diethyl ethoxymethylenemalonate (100 mL) were added to 680 mL of ethanol and heated under reflux for 5 h. The reaction mixture was cooled to precipitate a solid, suction filtrated, and the resulting solid was washed with petroleum ether to give 125.4 g of a pale yellow solid.

Provenance & Evidence