Diphenyl Ether → HCID 178469503, compound

Participants

Reaction Steps

Diethyl(2-(((6-bromopyridin-3-yl)amino)methylene)malonate (40 g, 0.117 mol) was added to boiling diphenyl ether (214 mL) in batches over 5 min, heated under reflux for 45 min. After confirming a disappearance of the raw materials by a thin layer chromatography plate (ethyl acetate:petroleum ether=1:3), the reaction mixture was cooled and poured into petroleum ether to precipitate a solid, suction filtered to give 24.6 g of a khaki solid.

Provenance & Evidence